In vitro Core
· In vivo toxicity testing is animal, time and cost intensive. In vitro approaches are needed for more rapid screening
of compounds and the eventual replacement of whole animal testing.
· Core capabilities include assessments of:
· Genotoxicity: Ames, comet, micronucleus assays
· Cytotoxicity with various relevant animal and human cell lines
· Mechanism of action determinations
· Unique exposures for cell lines and tissue models