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Naval Medical Research
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  • Naval 
Medical Research Unit - DaytonNaval Medical Research Center Unit - Dayton
    Dayton, OH
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 Environmental Health Effects Research

Researchers assess the toxicities of chemicals and materials via various routes of exposure at the molecular, cellular, organ and whole-body levels, all leading to derivation of state-of-the-science health protective exposure standards for our military and civilian populations serving on land, see, under the sea or air.
 
Environmental Toxicology
·         In vitro Screening of Fuels
·         In vivo Toxicity of Jet Fuels
·         Mechanisms of Toxicity
 
Inhalation Toxicology
·         Risk Assessment of Burn Pit Emissions
·         Risk Assessment of Particulate Matter
·         Toxicity studies of inhaled Nanomaterials
·         Health Risk Assessments of air contaminants in Pressurized Rescue Modules
·         Risks to Mixed Gender Crews in Submarines from atmospheric contaminants
 
Specialized Equipment:
·         Whole body inhalation chambers
·         Nose-only inhalation chambers
·         Hyperbaric Chamber
·         MED64 microelectrode array system for electrophysiology
·         Morris water maze and activity chambers
·         Distortion Product Otoacoustic Emissions (DPOAE) measurements

 

The Environmental Health Effects Research Directorate assesses the environmental and occupational health risks to our soldiers, sailors, airmen and marines with unique and state-of-the-art technologies. The inhalation systems are equipped with a diverse suite of analytical instrumentation capable of monitoring precise exposures to gases, vapors, aerosols, and particulates, including nanoparticles, as well as environmental conditions such as humidity, pressure, and temperature that may effect a response. Whole-body inhalation chambers and nose-only inhalation systems are fully automated to minimize manpower requirements for regulating test atmospheres and ensuring accurate data collection. Leach-style chambers are used for vapor uptake studies in rodents to provide data for physiologically based pharmacokinetic (PBPK) models. Research in neurobehavioral/cognitive sciences are supported by a proprietary neurobehavioral test battery, which assess exposure-induced changes in animals for motor coordination, locomotor function, emotionality, as well as learning and memory. Our facility also houses six primary labs dedicated to advanced bioinformatics, including genomics, transcriptomics, molecular biology, biochemical and analytical chemistry, with a tissue culture facility and state-of-the-art equipment in flow-cytometry and RT-PCR to identify mechanisms of toxic action and identify biomarkers of environmental toxicants that may affect the warfighter’s health.The Environmental Health Effects Research Directorate assesses the environmental and occupational health risks to our soldiers, sailors, airmen and marines with unique and state-of-the-art technologies. The inhalation systems are equipped with a diverse suite of analytical instrumentation capable of monitoring precise exposures to gases, vapors, aerosols, and particulates, including nanoparticles, as well as environmental conditions such as humidity, pressure, and temperature that may effect a response. Whole-body inhalation chambers and nose-only inhalation systems are fully automated to minimize manpower requirements for regulating test atmospheres and ensuring accurate data collection. Leach-style chambers are used for vapor uptake studies in rodents to provide data for physiologically based pharmacokinetic (PBPK) models. Research in neurobehavioral/cognitive sciences are supported by a proprietary neurobehavioral test battery, which assess exposure-induced changes in animals for motor coordination, locomotor function, emotionality, as well as learning and memory. Our facility also houses six primary labs dedicated to advanced bioinformatics, including genomics, transcriptomics, molecular biology, biochemical and analytical chemistry, with a tissue culture facility and state-of-the-art equipment in flow-cytometry and RT-PCR to identify mechanisms of toxic action and identify biomarkers of environmental toxicants that may affect the warfighter’s health.
 
     These capabilities have increased Tri-Service collaboration and enhanced the research activities associated with force health protection. NAMRU-D inhalation scientists are currently collaborating with Air Force Toxicologists in several research areas, including jet fuel toxicity and jet fuel plus noise co-exposures studies.These capabilities have increased Tri-Service collaboration and enhanced the research activities associated with force health protection. NAMRU-D inhalation scientists are currently collaborating with Air Force Toxicologists in several research areas, including jet fuel toxicity and jet fuel plus noise co-exposures studies.
 
 
 
 
Environmental Health Effects Research